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Saskia T C Neuteboom Selected Research

NB1011

7/2003NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint.
4/2002Inhibition of cell growth by NB1011 requires high thymidylate synthase levels and correlates with p53, p21, bax, and GADD45 induction.
1/2002Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011.

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Saskia T C Neuteboom Research Topics

Disease

13Neoplasms (Cancer)
12/2012 - 01/2002
3Multiple Myeloma
05/2011 - 11/2005
3Carcinoma (Carcinomatosis)
01/2006 - 01/2002
3Breast Neoplasms (Breast Cancer)
07/2003 - 01/2002
2Colonic Neoplasms (Colon Cancer)
11/2006 - 04/2002
1Pancreatic Neoplasms (Pancreatic Cancer)
12/2012
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
12/2012
1Lung Neoplasms (Lung Cancer)
12/2012
1Melanoma (Melanoma, Malignant)
12/2012
1Adenocarcinoma
05/2011
1Pain (Aches)
12/2010

Drug/Important Bio-Agent (IBA)

8marizomibIBA
12/2012 - 06/2005
5Proteasome Endopeptidase Complex (Proteasome)IBA
12/2012 - 11/2006
4Proteasome InhibitorsIBA
12/2012 - 06/2005
3Thymidylate SynthaseIBA
07/2003 - 01/2002
3NB1011IBA
07/2003 - 01/2002
3Proteins (Proteins, Gene)FDA Link
07/2003 - 01/2002
2NPI 2358IBA
12/2010 - 01/2006
2Biological ProductsIBA
12/2010 - 01/2006
2Pharmaceutical PreparationsIBA
02/2005 - 04/2002
2DNA (Deoxyribonucleic Acid)IBA
07/2003 - 04/2002
2EnzymesIBA
07/2003 - 04/2002
2raltitrexed (D 1694)IBA
04/2002 - 01/2002
1VorinostatFDA Link
12/2012
1Histone Deacetylases (Histone Deacetylase)IBA
12/2012
1Histone Deacetylase InhibitorsIBA
12/2012
1HeptanesIBA
05/2011
1RANK LigandIBA
10/2007
1ChymotrypsinFDA Link
02/2007
1NF-kappa B (NF-kB)IBA
11/2006
1DiketopiperazinesIBA
01/2006
1TubulinIBA
01/2006
1Bortezomib (Velcade)FDA Link
11/2005
1lajollamycinIBA
02/2005
1phosphoramidic acidIBA
07/2003
1brivudine (brivudin)IBA
07/2003
1Irinotecan (Camptosar)FDA LinkGeneric
04/2002
14-nitrobenzylthioinosineIBA
01/2002
1NucleosidesIBA
01/2002
1Dipyridamole (Persantine)FDA LinkGeneric
01/2002
1Antineoplastic Agents (Antineoplastics)IBA
01/2002
1Fluorouracil (Carac)FDA LinkGeneric
01/2002

Therapy/Procedure

2Therapeutics
11/2006 - 11/2005
1Drug Therapy (Chemotherapy)
11/2006